La Croixs Natural Flavors Were Not a Mystery. Odds are pretty good that you have consumed a food or beverage item in the past 2. In fact, theres a non zero chance you are ingesting one right now. The term is a catch all for an enormous number of different ingredients, but the ambiguity of the label does not make any one processed food or drink product an unsolvable enigma. Unless, apparently, the food product in question is La Croix, the extremely normal, Midwestern brand of flavored sparkling water which has become an annoyingly trendy status symbol and lifestyle brand. Earlier this week, a Wall Street Journal article supposedly cracked the brands code and revealed what its natural flavors are, while extensively quoting people who seem to have walked out of a Harry Potter themed La Croix ad. La Croix would only tell the paper its natural flavoring is essence and that essence is FEELINGS and Sensory Effects Well get to what essence actually is in a second, but heres what its customers think it is. Essence is, like, a combination of hint and aftertaste, Antony Merkel, a 3. Los Angeles resident who said he drinks 1. La Croix a day, breathlessly told the Journal. You definitely recognize the flavors that are there, but it doesnt feel like youre drinking a product of that, Merkel continued. Its not a grapefruit juice, or something of a grapefruit. Its a little intangible, which is kind of the appeal. I have no idea what it is. Essence is fairies in a warehouse somewhere dancing with fruits, and suddenly you have this amazing drink, 3. Atlanta social media manager Miranda Wicker added. There are just some things we dont need to know. Because La Croix is the Game of Thrones of non alcoholic beverages, the story was immediately picked up by a number ofother outlets. But again, theres no mystery here, just marketing. Natural flavoring is any sort of chemical originally extracted or distilled from a natural sourcerather than artificially synthesizedto create a concentrate that is then used in the manufacturing of a food or drink. Sometimes, theyre mixed with other additives, some of which are synthetic, before being added to food and drink. Essence in this context is just a catchy term for essential oil, the concentrated form of the chemicals which give a plant its fragrance. Some essential oils are useful in medicine as antiseptics or anesthetics, while others are often used in industrial processes, cosmetics and hygienic products. Because theyre highly concentrated, theyre an invaluable part of the food industry Essential oils can be distilled and packaged wherever it is logistically easiest and sold off for use in a huge variety of products. So theres your natural flavoring The magical essence behind La Croix is nothing more than a marketing buzzword to describe the same manufacturing processes behind almost all processed foodstuffs. It is fruit skins and rinds that have been crushed up and heated until the mix releases its essential oils. Also, this information was freely available on La Croixs website the whole time. Buzzfeed, Wall Street Journal.
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Introduccin.Epidemiologa de la enfermedad.Tipos de vacunas, composicin y presentacin.Inmunogenicidad, eficacia y efectividad.Vas de administracin.VIERNES 29 DE SEPTIEMBRE DEL 2017.PODER EJECUTIVO Decreto Ejecutivo Nmero PCM0622017.PODER LEGISLATIVO Decreto No.JUEVES 21 DE SEPTIEMBRE DEL 2017.Portal Imprenta Nacional Hermes Soluciones de Internet.DECRETOS N 40264MP.LA SEGUNDA VICEPRESIDENTA EN EJERCICIO.DE LA PRESIDENCIA DE LA REPBLICA.Nro asunto expedicion ver 0001 articulo primero autorizar al policlinico andralex e.Manual Oficial De Seguridad Vial Activa' title='Manual Oficial De Seguridad Vial Activa' />Indicaciones y esquemas de vacunacin.Recomendaciones de vacunacin.Administracin con otras vacunas y otros productos.Efectos adversos.Precauciones y contraindicaciones.Observaciones sobre la invaginacin intestinal.Observaciones relacionadas con la presencia de circovirus.Bibliografa. Enlaces de Inters.Tablas incluidas en el captulo.Tabla 3. 5. 1. Principales caractersticas de las dos vacunas frente al rotavirus1.Puntos clave. El rotavirus RV es la causa principal de diarrea infantil grave en todo el mundo e infecta prcticamente a todos los nios en los 5 primeros aos de vida, sobre todo en los primeros 2 aos.La persistencia en la infancia de una alta morbilidad por rotavirus, independientemente de la mejora en las condiciones higinicas y sanitarias, sita a la vacunacin como la nica estrategia con posibilidad de impacto en la prevencin de la enfermedad.El objetivo de estas vacunas ha sido reproducir la historia natural de la infeccin proteger frente a la enfermedad grave en los primeros meses de vida.Los estudios poscomercializacin en los pases industrializados en los que se vacuna sistemticamente frente al RV indican que puede ocurrir invaginacin como consecuencia de esta vacunacin, pero el riesgo es bajo, de aproximadamente 1 a 5 casos por 1.Por tanto, debemos mantener una vigilancia activa de las reacciones adversas de las vacunas frente al rotavirus, fundamentalmente de la posibilidad de invaginacin intestinal, informando a los padres de los nios que van a ser vacunados de los beneficios y riesgos de esta vacuna, y explicando claramente los signos de alarma de invaginacin intestinal, para poder actuar con rapidez y evitar las complicaciones de un diagnstico diferido.Existen 2 vacunas frente al rotavirus, pentavalente bovina humana Rota.Teq y monovalente humana Rotarix, ambas atenuadas y de administracin oral, que han demostrado ser seguras y eficaces frente a la enfermedad y que no interfieren con las vacunas del calendario vigente.Se recomienda la vacunacin frente al rotavirus en todos los lactantes.Introduccin. La gastroenteritis aguda GEA, cuya expresin clnica es un cuadro de diarrea y vmitos, es una de las enfermedades ms comunes en nios y la segunda causa de morbilidad y mortalidad en la edad infantil a escala mundial.La causa ms frecuente es la infeccin gastrointestinal y el principal agente el rotavirus del grupo A.La gastroenteritis por rotavirus GEA RV se asocia a una mayor gravedad que la causada por otros agentes infecciosos, con ms riesgo de deshidratacin y de necesidad de hospitalizacin, dndose principalmente entre los 6 y 2.La historia natural de la enfermedad muestra una alta incidencia de infecciones repetidas en los 2 primeros aos de vida, gran parte de ellas asintomticas, y una disminucin de la gravedad del cuadro clnico con el nmero de infecciones.Se trata de un proceso autolimitado y de corta duracin.No existe un tratamiento especfico de la GEA RV como tal, por lo que ste es exclusivamente sintomtico.Epidemiologa de la enfermedad.Los estudios epidemiolgicos permiten estimar que la infeccin por rotavirus se da prcticamente en todos los nios durante los primeros 5 aos de vida.En pases en vas de desarrollo es una causa importante de mortalidad.En pases industrializados se asocia a una gran morbilidad, aunque con una muy baja mortalidad e incidencia de secuelas.En la Unin Europea se ha estimado una incidencia anual de infeccin sintomtica por rotavirus de cualquier gravedad de 1.Los recientes estudios prospectivos de vigilancia realizados en distintos pases europeos, incluido Espaa, han confirmado la asociacin de rotavirus a una forma de enfermedad ms grave, con una mayor frecuencia de deteccin de rotavirus 4.En Espaa, el RV es responsable del 1.Tambin se asocia con una alta utilizacin de recursos sanitarios visitas a urgencias y a Atencin Primaria.La GEA RV cuesta al Sistema Nacional de Salud espaol 2.Desde la introduccin de la vacunacin en el ao 2.En un artculo reciente de Aliabadi y cols.Estados Unidos en el ao 2.Tras la introduccin de la vacuna se apreci una disminucin en la deteccin de rotavirus, entre el 5.Estos resultados demuestran la efectividad de la vacuna en la reduccin de la circulacin y los cambios mantenidos de la epidemiologa de los rotavirus entre los nios estadounidenses figura 3.En pases de Latinoamrica se ha descrito una disminucin del 6.GEA RV y del 3. 0 4.En Europa y Australia, en los pases con implantacin de un programa de vacunacin universal se ha observado una disminucin en la hospitalizacin por GEA RV en menores de 5 aos del 6.La observacin de la disminucin de la tasa de hospitalizacin en nios ms mayores, no vacunados, implica la existencia de una proteccin indirecta o inmunidad tipo rebao.Figura 3. 5. 1. Disminucin de incidencia de GEA RV en EE.UU. Duracin de la temporada de rotavirus y picos de actividad mxima por aos etapa prevacunal 2.Datos del Sistema Nacional de Vigilancia de Virus Respiratorios y Entricos del CDC NREVSS.Estados Unidos, 2.Tomado de Aliabadi N, et al.Sustained Decrease in Laboratory Detection of Rotavirus after Implementation of Routine Vaccination United States, 2.MMWR. 2. 01. 5 6.Tipos de vacunas, composicin y presentacin.Las dos vacunas disponibles en Europa y en el resto del mundo son tabla 3.Pentavalente bovina humana reordenada Rota.Teq, de Sanofi Pasteur MSD utiliza la cepa de rotavirus bovino WC3.Contiene cinco cepas atenuadas, obtenidas por recombinacin gentica entre esta cepa y cepas de rotavirus humanos, que expresan cada una la protena de superficie VP7 de los rotavirus humanos de los tipos G1, G2, G3 y G4 y la protena VP4 del rotavirus humano correspondiente al genotipo P8.Contiene sacarosa.Monovalente humana atenuada Rotarix, de Glaxo.Smith. Kline Biologicals la cepa inicial era un rotavirus humano con especificidad G1 P8 aislado de un nio con gastroenteritis.Esta cepa fue clonada y pasada por cultivos de clulas Vero para su atenuacin, obtenindose la cepa vacunal RIX4.Incluye como aditivos sacarosa y sorbitol.Las dos vacunas se presentan en formulacin oral lquida, en aplicador oral o en tubo precargado, y han de conservarse a 2 8C, con una validez de 3 aos monovalente humana y 2 aos pentavalente bovina humana.En el caso de Rotarix se trata de un lquido transparente e incoloro en el de Rota.Teq el lquido es transparente amarillo plido y puede tener un tono rosado.Tabla 3. 5. 1. Principales caractersticas de las dos vacunas frente al rotavirus.Nombre comercial.RotarixRota. TeqLaboratorio.Glaxo. Smith. Kline Biologicals.Sanofi Pasteur MSD EuropaMerck and Co., Inc.EE. UU. Tipo de vacuna.Monovalente humana atenuada.Pentavalente bovina humana reordenada.Cepas vacunales. RIX4. Best Free Sip Software Windows . Bovina WC3 G6. P75Reordenadas humana bovina G1 x WC3 G2 x WC3.G3 x WC3 G4 x WC3.P8x WC3. Tipos incluidos G1.P8 G1, G2, G3, G4, P8Dosis.Dosis 1,5 ml. No menos de 1.CCID5. 0Dosis 2 ml.No menos de 2,2 x 1.UI G1 2,8 x 1.UI G2 2,2 x 1.UI G3 2,0 x 1.UI G4 2,3 x 1.UI P18Presentacin Lquida con buffercarbonato de calcio Lquida con buffercitrato y fosfato sdicoCCID5.UI unidades infecciosas5.Inmunogenicidad, eficacia y efectividad.Todava no estn claros los factores especficos de respuesta inmune que se puedan considerar como marcador de proteccin.Por ello, en los ensayos con las vacunas se ha empleado como medida de inmunogenicidad la elevacin srica de los ttulos de anticuerpos Ig.A y como medida de eficacia la disminucin en la incidencia de GEA RV en el grupo vacunado respecto al grupo control.Inmunogenicidad. Vacuna pentavalente bovina humana las tasas de seroconversin tras la tercera dosis han sido del 9.Vacuna monovalente humana los porcentajes de seroconversin en Latinoamrica han sido de 6.En el estudio europeo las tasas de seroconversin observadas fueron del 8.Eficacia. Vacuna pentavalente bovina humana el estudio de eficacia y seguridad en fase III realizado con esta vacuna en 6.Centro de noticias de la ONU en espaol.Aos de conflictos armados han dejado las tierras de Somalia sembradas de trampas mortales minas y otros explosivos sin detonar.El Servicio de las Naciones Unidas de Actividades relativas a las Minas UNMAS, gracias a la financiacin del Gobierno de Japn, ayuda al pueblo somal a reducir los peligros de dejan tras s las guerras. 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